Culture subject nyt crossword: How to solve this tricky clue

If you are a fan of crossword puzzles, you might have come across the clue “culture subject” in the New York Times crossword of December 23, 2022. This clue, created by Brandon Koppy and edited by Will Shortz, has 12 letters and is quite difficult to solve. In this article, we will give you some tips and hints on how to crack this clue and find the correct answer.

What is a culture subject?

Before we dive into the possible solutions, let us first understand what a culture subject is. A culture subject is a term that refers to something that is grown or cultivated in a laboratory, such as bacteria, fungi, cells, tissues, or organs. These culture subjects are used for various purposes, such as scientific research, medical diagnosis, biotechnology, or drug development. According to Levels Answers, culture subjects are often stored in petri dishes, test tubes, flasks, or bioreactors.

How to approach the clue

Now that we know what a culture subject is, how can we approach the clue and find the answer? One way to do this is to use the process of elimination. We can start by listing all the possible words that have 12 letters and are related to culture subjects. Some examples are:


Next, we can look at the crossword grid and see if any of these words fit the pattern of the clue. For example, if we know that the first letter is T and the last letter is E, we can eliminate all the words that do not match this criterion. This leaves us with only one word: TISSUESAMPLE.

Why is TISSUESAMPLE the correct answer?

A tissue sample is a culture subject that consists of a small piece of tissue taken from a living organism, such as a human, an animal, or a plant. A tissue sample can be used for various purposes, such as testing for diseases, studying the structure and function of cells, or developing new treatments. According to NYT Crossword Answers, a tissue sample is a common term in medicine and biology, and it fits the definition of a culture subject perfectly.

Therefore, the correct answer to the clue “culture subject” is TISSUESAMPLE. Congratulations, you have solved this tricky clue and completed the crossword puzzle!